GlaxoSmithKline plc

26 April 2017, London UK

NOTICE

To the Holders of
5.375% Notes due 2034 CUSIP # 377372 AB3
of GlaxoSmithKline Capital Inc.

NOTICE IS HEREBY GIVEN, pursuant to Section 8.08 of the Indenture, dated as of April 6, 2004, as amended and supplemented by the First Supplemental Indenture dated as of March 18, 2013 and by the Second Supplemental Indenture dated as of March 21, 2014 (the "Indenture"), by and among GlaxoSmithKline Capital Inc., GlaxoSmithKline plc, as guarantor, and Law Debenture Trust Company of New York, as Trustee, that Law Debenture Trust Company of New York has resigned as trustee, registrar, paying agent and authenticating agent under the Indenture.

Pursuant to Section 8.08 of the Indenture, Deutsche Bank Trust Company Americas, a banking corporation duly organized and existing under the laws of New York, has accepted appointment as trustee, registrar, paying agent and authenticating agent under the Indenture.  The address of the designated corporate trust office of the successor Trustee is 60 Wall Street, 16th Floor, New York, NY 10005.

Law Debenture Trust Company of New York's resignation as trustee, registrar and paying agent and Deutsche Bank Trust Company America's appointment as successor trustee, registrar, paying agent and authenticating agent were effective as of the opening of business on April 26, 2017.

Dated: April 26, 2017

GLAXOSMITHKLINE CAPITAL INC.