For immediate release

Circassia Pharmaceuticals plc

Persons Discharging Managerial Responsibilities and persons closely associated with them notification

Oxford, UK - 5 June 2017: Circassia Pharmaceuticals plc ("Circassia" or "the Company") (LSE: CIR) Persons Discharging Managerial Responsibilities and persons closely associated with them notification.

This form is for the use of persons discharging managerial responsibilities (PDMRs) as well as persons closely associated with them to notify transactions to the FCA under Article 19(1) of Regulation (EU) No 596/2014 of the European Parliament and of the Council on market abuse ("The Market Abuse Regulation").

Once this form has been sent to the designated email address, it constitutes the "secure means of transmission" mandated in Article 2 of Regulation (EU) 2016/523. PDMRs as well as persons closely associated with them are required to use this form when submitting a notification under this article.

PDMR Notification Form Page

1 - Details of the person discharging managerial responsibilities/person closely associated

2 - Reason for the notification

3 - Details of the issuer, emission allowance market participant, auction platform, auctioneer or auction monitor

4 - Details of the transaction(s)

Details of the transaction(s): section to be repeated for (i) each type of instrument; (ii) each type of transaction; (iii) each date; (iv) each place where transactions have been conducted

i.          Exercise of options

ii.         Sale of shares following exercise of options

-Ends-