Fulcrum Pharma PLC
22 January 2008


                               FULCRUM PHARMA PLC

                                ("the Company")

                             Director Shareholding

The Company has been informed that Geoffrey Smith, Finance Director, yesterday
bought 500,000 ordinary shares in the Company at a price of 3.5p per share.

As a result, Mr Smith now holds 3,732,744 ordinary shares, representing
approximately 2.1% per cent of the current issued share capital of the Company.




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