22nd October 2009

                       REGEN THERAPEUTICS PLC
              ("ReGen" or the "Company"; Ticker: (RGT))


TR-1(i): NOTIFICATION OF MAJOR INTEREST IN SHARES



1. Identity of the issuer or the underlying    ReGen Therapeutics Plc
issuer of existing shares to which voting
rights are attached (ii):


2. Reason for the notification:                An acquisition or
                                               disposal of voting
                                               rights


3. Full name of person(s) subject to the       Barclays PLC
notification obligation (iii):


4. Full name of shareholder(s) (if difference  Barclays Stockbrokers
from 3):                                       Ltd


5. Date of the transaction and date on which   21st October 2009
the threshold is crossed or reached (v):


6. Date on which issuer notified:              22nd October 2009


7.  Threshold(s) that is/are crossed or        13% to 12%
reached:

8.  Notified details

A: Voting rights attached to shares

Class/type of share if possible using the ISIN GB00B28XMY25
Code

Situation Previous to the triggering
transaction (vi) -
Number of Shares                               4,464,897
Number of Voting Rights (viii)                 4,464,897

Resulting situation after the triggering
transaction (viii) -
Number of Shares                               4,399,902
Number of Voting Rights - Direct (x)           N/A
Number of Voting Rights - Indirect (xi)        4,399,902
% of voting rights - Direct                    N/A
% of voting rights - Indirect                  12.85

B: Financial Instruments

Resulting situation after the triggering
transaction (xii)

Type of financial instrument                   N/A
Expiration date (xiii)                         N/A
Exercise/Conversion Period/Date (xiv)          N/A
Number of voting rights that may be acquired   N/A
if the instrument is exercised/converted
% of voting rights                             N/A

C: Financial Instruments with similar economic effect to Qualifying
Financial Instruments

Resulting situation after the triggering
transaction

Type of financial instrument                   N/A
Exercise Price                                 N/A
Experation Date                                N/A
Number of voting rights                        N/A
Instrument refers to
% of voting rights                             N/A

Total (A+B+C)


Number of voting rights                        4,399,902
% of voting rights                             12.85


9.  Chain of controlled undertakings through   Barclays Stockbrokers
which the voting rights and/or the financial   Ltd
instruments are effectively held, if
applicable (xv):

Proxy Voting:

10. Name of the proxy holder:                  N/A
11. Number of voting rights proxy holder will  N/A
cease to hold:
12. Date on which proxy holder will cease to   N/A
hold voting rights:
13. Additional information:                    N/A
14. Contact name:                              Geoff Smith
15. Contact telephone number:                  0207 116 2913






For further information:

For further information, please contact:
Percy Lomax
ReGen Therapeutics Plc
Tel: 020 7153 4920

Roland Cornish/Felicity Geidt
Beaumont Cornish Limited
Tel: 020 7628 3396

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