Notification of major interests in shares


October 31, 2014 - Shire plc (LSE: SHP, NASDAQ: SHPG)


1. Identity of the issuer or the underlying issuer of existing shares to  Shire plc
which voting rights are attached:



2. Reason for the notification                                            State
                                                                          Yes/
                                                                          No

An acquisition or disposal of voting rights                               Yes

An acquisition or disposal of qualifying financial instruments which may
result in the acquisition of shares already issued to which voting rights
are attached                                                              No

An acquisition or disposal of instruments with similar economic effect to
qualifying financial instruments
                                                                          No

An event changing the breakdown of voting rights                          No

Other (please specify):                                                   No




3. Full name of person(s) subject to the notification obligation:  FMR LLC

4. Full name of shareholder(s) (if different from 3.):             See Section 9


5. Date of the transaction (and date on which the threshold is     30th October 2014
crossed or reached if different):

6. Date on which issuer notified:                                  31st October 2014


7. Threshold(s) that is/are crossed or reached:                    5%


8. Notified details:

A: Voting rights attached to shares



             Situation previous to Resulting situation after the triggering
             the Triggering        transaction
Class/type   transaction
of shares
 if possible Number     Number     Number     Number of voting  % of voting
using the    of         of         of         rights            rights
ISIN CODE    Shares     Voting     shares
                        Rights

                                   Indirect   Direct Indirect   Direct Indirect




JE00B2QKY057 29,221,937 29,221,937 29,648,433        29,648,433         5.02



B: Qualifying Financial Instruments



Resulting situation after the triggering transaction



Type of         Expiration Exercise/        Number of voting        % of
financial       date       Conversion       rights that may be      voting
instrument                 Period/ Date     acquired if  the        rights
                                            instrument
                                            is exercised/converted




C: Financial Instruments with similar economic effect to Qualifying Financial
Instruments



Resulting situation after the triggering transaction



Type of        Exercise Expiration Exercise/  Number of      % of voting
financial      price    date       Conversion voting         rights
instrument                         period     rights
                                              instrument
                                              refers to

                                                             Nominal  Delta




Total (A+B+C)

Number of voting rights                     % of voting rights

29,648,433                                  5.02



9. Chain of controlled undertakings through which the voting rights and/or the
financial instruments are effectively held, if applicable:

Custodian                      Day to Day IM                                     Total

                               CROSBY ADVS LLC-CROSBY ADVISORS LLC                   16,700

BANK OF NEW YORK MELLON        FMRC-FMR CO., INC                                     18,800

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                  160,094

BROWN BROTHERS HARRIMAN AND CO FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC.     42,900

                               FMRC-FMR CO., INC                                  6,548,374

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                   16,530

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY          264,879

CIBC MELLON TRUST (C)          PGA ULC-PYRAMIS GLOBAL ADVISORS (CANADA) ULC          38,200

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    6,523

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY           13,200

CITIBANK NA                    FMRC-FMR CO., INC                                  3,724,065

CITIBANK NA, HONG KONG BR (S)  PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    7,197

DEUTSCHE BANK ALEX BROWN (C)   PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    3,600

GOLDMAN SACHS AND CO           PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    7,200

JP MORGAN, BOURNEMOUTH (C)     PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    3,257

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY           16,395

JPMORGAN CHASE BANK            FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC.    422,700

                               FMRC-FMR CO., INC                                  7,704,519

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                      900

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY           13,523

                               SELECTCOLLC-FIDELITY SELECTCO, LLC                       150

MELLON BANK NA (C)             PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                   48,242

MORGAN STANLEY AND CO LLC      PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    1,200

NATIONAL BANK TRUST (C)        PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY            6,880

NATIONAL FINANCIAL SERVICES(C) SAI-STRATEGIC ADVISERS, INC.                           1,603

NORTHERN TRUST CO (C)          FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC.  1,110,100

                               FMRC-FMR CO., INC                                  1,972,600

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                   88,401

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY           11,550

ROYAL TRUST- TORONTO (C)       PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY            4,043

STATE STR BK AND TR CO LNDN (C PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    5,172

STATE STREET BANK AND TR CO    FMR UK-FIDELITY MANAGEMENT & RESEARCH (U.K.) INC.    532,100

                               FMRC-FMR CO., INC                                  5,960,380

                               PGA ULC-PYRAMIS GLOBAL ADVISORS (CANADA) ULC         504,500

                               PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                  228,057

                               PGATC-PYRAMIS GLOBAL ADVISORS TRUST COMPANY          136,032

US BANK NA (C)                 PGALLC-PYRAMIS GLOBAL ADVISORS, LLC                    7,868

Grand Total                                                                      29,648,433



Proxy Voting:

10. Name of the proxy holder:                               FMR LLC

11. Number of voting rights proxy holder will acquire:      426,496

12. Date on which proxy holder will acquire voting rights:  30th October 2014




13. Additional information:       None

14. Contact name:                 Nina Collomosse

15. Contact telephone number:     fil-regreporting@fil.com, 01737 837092




Contact at Shire plc: Tony Guthrie, Deputy Company Secretary, 01256 894746

For further information please contact:



Investor Relations

Jeff Poulton              jpoulton@shire.com          +1 781 482 0945

Sarah Elton-Farr          seltonfarr@shire.com        +44 1256 894157




NOTES TO EDITORS


Shire enables people with life-altering conditions to lead better lives.

Our strategy is to focus on developing and marketing innovative specialty
medicines to meet significant unmet patient needs.

We focus on providing treatments in Neuroscience, Rare Diseases,
Gastrointestinal, and Internal Medicine and we are developing treatments for
symptomatic conditions treated by specialist physicians in other targeted
therapeutic areas, such as Ophthalmology.

www.shire.com